About the database
Much new information has accumulated since the inception of the original DExH/D Protein database. It is now clear that there are well defined DExH/D protein subgroups. We have therefore structured the information on DExH/D proteins according to these subgroups.
Because of the constant influx of new sequence information, we felt unable to aim for comprehensive coverage of all newly sequenced DEAD-box proteins. We have therefore restricted the coverage to DExH/D proteins from S. cerevisiae, C. elegans, M. musculus, and H. sapiens, and representative viral and bacterial proteins. We believe this is a sensible selection that illustrates phylogenetic relationships between the DExH/D proteins.
We have also aimed to minimize information redundant with data in primary sequence and literature databases. However, we extensively link to the specific protein and literature sites in the primary databases.
The database also contains auxillary information on DExH/D proteins, including lists of structures, reviews, and labs, as well as a curated DExH/D protein primer.
This database was created by Anja and Eckhard Jankowsky. Eckhard developed the concept. All aspects of design and technical and graphical implementation were realized by Anja. The scientific content was compiled by Anja and Eckhard with help from Maggie Fairman.
Eckhard is Associate Professor of Biochemistry at Case Western Reserve University in Cleveland, Ohio. Work in his lab is focussing on roles and mechanisms of RNA helicases.